The broad-spectrum fungicide Captan (captan) is used by some growers late in the season to specifically control a variety of bunch rots as well as downy mildew. In studies done in California in the 1950s, captan residues of at least 1 mg/L delayed alcoholic fermentation by 20 to 40 hours, but did not prevent the proper completion of fermentation once it had started. The degree of delay was related to the amount of residue, with smaller amounts only causing slight delays.
However, wines prepared from captan-treated grapes retained a definite cloudiness after six months of storage, but the cloudiness could be removed by filtration. Another study showed that Captan was degraded in grape must and was only found as its metabolite (THPI) in wine. The degradation of captan to THPI was due to the acidity in must and wine. This metabolite was present at low levels on grapes, and, unlike captan, had no negative effect on the fermentative process.


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